Drosophila CNS Glutamate Receptors Break the Rules

588 views · Published 7 December 2016 · 5:41 · Indexed 16 October 2026

Channel: Cell Press · 2016 · Science & Technology

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For more information, see Li et al., Neuron 92(5), http://www.cell.com/neuron/fulltext/S0896-6273(16)30808-X.

Using structural and electrophysiological techniques Li, Dharkar et al. find that Drosophila CNS glutamate receptors have unexpected ligand selectivity. The kainate receptor DKaiR1D is inhibited by NMDA and AP5, while DGluR1 is weakly activated by its namesake agonist AMPA.

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