Computer Simulations Predict High Structural Heterogeneity of Functional State of NMDA Receptors

1,445 views · Published 4 September 2018 · 0:20 · Indexed 25 September 2026

Channel: Cell Press · 2018 · Science & Technology

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Freely behaving NMDA receptors: neuronal NMDA receptors were characterized with several frozen X-ray and cryoEM structures, but their dynamics in vivo are even more difficult to study. The article by Sinitskiy and Pande (https://www.cell.com/biophysj/fulltext/S0006-3495(18)30728-8) in the September 4 issue of Biophysical Journal reports on large-scale computer simulations of NMDARs, revealing their rich structural heterogeneity and fast dynamics.

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