A Conformational Twist for GPCR Signaling/ Cell, October 6, 2016 (Vol.. 167, Issue 3)

2,449 views · Published 11 October 2016 · 3:50 · Indexed 10 November 2026

Channel: Cell Press · 2016 · Science & Technology

Watch on YouTube

We know that different ligands induce conformational changes in G protein-coupled receptors to modulate different signaling responses. However, Dr. Patrick Sexton and his colleagues of Monash University in Australia in this Cell paper reveal an additional layer of regulation by showing that the G-protein also adopts different conformations to influence downstream signaling. This provides an important framework for design better and safer drugs. Check out the paper at:  http://www.cell.com/cell/fulltext/S0092-8674(16)31254-5.

Sebastian George Barton Furness, Yi-Lynn Liang, Cameron James Nowell, Michelle Louise Halls, Peter John Wookey, Emma Dal Maso, Asuka Inoue, Arthur Christopoulos, Denise Wootten, and Patrick Michael Sexton (2016). Ligand-Dependent Modulation  of G Protein Conformation Alters Drug Efficacy. Cell 167

And read more great research at http://www.cell.com/cell/home.

More from this channel

• 2:55 Chromatin shapes the mitotic spindle

  Cell Press

  3,101 views · 30 July 2009

• 5:14 The architecture of adaptation

  Cell Press

  1,732 views · 10 August 2009

• 4:14 Wnts come in small packages

  Cell Press

  2,573 views · 6 October 2009

• 6:09 Helicases Find Their Way

  Cell Press

  4,304 views · 4 November 2009

• 3:16 Fighting Mosquito-Borne Infections

  Cell Press

  2,585 views · 14 December 2009

• 4:29 Leaving Trash with Moms Keeps Daughters Young

  Cell Press

  2,287 views · 21 January 2010

• 4:07 Feedback Control of Vocal Learning

  Cell Press

  704 views · 27 January 2010

• 4:22 DISC1 knockdown leads to behavioral deficits

  Cell Press

  1,789 views · 10 February 2010