Ultraslow Water-Mediated Transmembrane Interactions Regulate Activation of A2A Adenosine Receptor
601 views · Published 20 September 2016 · 0:14 · Indexed 10 November 2026
Channel: Cell Press · 2016 · Science & Technology
Water dynamics in the apo form of A2A adenosine receptor. Water molecules inside transmembrane domain are highly dynamic in general; however, some of the water molecules are slow enough to mediate interactions around the key micro-switch residues depicted with stick representation. See the article by Lee et al. in the September 20 issue of Biophysical Journal (http://www.cell.com/biophysj/fulltext/S0006-3495(16)30658-0).
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