Phospholipid Enters Receptor's G-Protein Binding Site

1,008 views · Published 20 October 2015 · 0:18 · Indexed 10 November 2026

Channel: Cell Press · 2015 · Science & Technology

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A phospholipid from the membrane's cytosolic leaflet (yellow) enters the empty G-protein binding site of an activated beta 2 adrenergic receptor and forms salt-bridge interactions that inhibit ionic lock formation and prolong active-state residency in a 14 µs atomistic molecular dynamics simulation (viewed from cytosol). See the article by Neale et al. in the October 20 issue of Biophysical Journal.

Read more at http://www.cell.com/biophysj/abstract/S0006-3495(15)00863-2

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