Nesprin1 Railroad Tracks Direct RNA from Nucleus to Synapse

497 views · Published 20 May 2015 · 4:32 · Indexed 4 November 2026

Channel: Cell Press · 2015 · Science & Technology

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Pachard et al. uncover a novel pathway where giant Nesprin1 and F-actin form tracks from the nucleus to developing synapses.  The formation of these tracks is critical for the localization of specific mRNAs, which are required to synthesize the postsynaptic region.
Check out the paper at http://www.cell.com/neuron/abstract/S0896-6273(15)00335-9.

M. Packard, V. Jokhi, B. Ding, C. Ruiz-Cañada, J. Ashley, V. Budnik. (2015). Nucleus to Synapse Nesprin1 Railroad Tracks Direct Synapse Maturation through RNA Localization. Neuron 86. 

And read more great research at http://www.cell.com/neuron/home.

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