Subdomain Targeting by Cooperating Axon-Axon Signaling and Chemoattraction
665 views · Published 16 July 2014 · 6:51 · Indexed 6 November 2026
Channel: Cell Press · 2014 · Science & Technology
The habenula is organized in different subnuclei that receive specific afferent inputs. Jeroen Pasterkamp and colleagues show how pretarget axon-axon interactions, mediated by the cell adhesion molecule LAMP, and chemoattraction, by the guidance cue Netrin-1, cooperate to selectively direct dopaminergic afferents to the lateral habenula. For more information, see Schmidt et al. in Neuron 83/2, http://www.cell.com/neuron/abstract/S0896-6273(14)00451-6.
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