Structural Insights into Competitive Antagonism in NMDA Receptors

3,616 views · Published 22 January 2014 · 3:43 · Indexed 17 October 2026

Channel: Cell Press · 2014 · Science & Technology

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Overactive N-methyl-D-aspartate (NMDA) receptors are implicated in several neurological disorders. However, mechanistic understanding of antagonism in NMDA receptors is limited due to a lack of antagonist-bound structures. Here, structures of antagonist-bound ligand-binding domains of NMDA receptors are presented. For more information, see Jespersen et al., Neuron 81(2).

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