Ephemeral Protein Binding to DNA Shapes Stable Nuclear Bodies and Chromatin Domains
333 views · Published 28 March 2017 · 0:15 · Indexed 18 October 2026
Channel: Cell Press · 2017 · Science & Technology
Movie following the dynamics of two clusters of chromatin-binding proteins (chromatin omitted for clarity). Proteins switch between an "on" (binding) and an "off" (non-binding) state at constant rate, leading to continuous exchange of proteins between the clusters and the soluble pool, as observed experimentally for nuclear bodies. Proteins are color-coded according to the cluster they belong to initially; gray proteins are not in clusters initially. See the article by Brackley et al. in the March 28 issue of Biophysical Journal (http://www.cell.com/biophysj/fulltext/S0006-3495(17)30146-7).
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