Extracellular Fuel for Metastasis

1,567 views · Published 15 January 2015 · 5:53 · Indexed 28 October 2026

Channel: Cell Press · 2015 · Science & Technology

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Cancer cells enhance their ability to metastasize by producing phospho-creatine, a metabolite that fuels metastatic survival, in the extracellular space. This process can be interrupted by administration of specific miRNAs or a small-molecule inhibitor, demonstrating the therapeutic potential of targeting this process.
Read the full article, Jia Min Loo, Alexis Scherl, Alexander Nguyen, Fung Ying Man, Ethan Weinberg, Zhaoshi Zeng, Leonard Saltz, Philip B. Paty, and Sohail F. Tavazoie (2015) Extracellular Metabolic Energetics Can Promote Cancer Progression. Cell 160. 

Available at: http://www.cell.com/cell/abstract/S0092-8674%2814%2901588-8

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