Cholesterol Binding to TCR-β Keeps the TCR in the Inactive Conformation
668 views · Published 17 May 2016 · 1:01 · Indexed 31 October 2026
Channel: Cell Press · 2016 · Science & Technology
The TCR can adopt an inactive, resting or an active, primed state. This video summarizes the findings of Schamel and colleagues showing that the TCR is in equilibrium between these states. Peptide-MHC binding stabilizes the primed state that can be phosphorylated. Cholesterol binding stabilizes the resting state and thereby tunes the TCR activation threshold.
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