How cells in liquid suspension migrate

462 views · Published 16 July 2018 · 0:21 · Indexed 27 October 2026

Channel: Cell Press · 2018 · Science & Technology

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Here O’Neill et al. use optogenetic methods to drive cell migration, illustrating how RhoA activation in the back of the cell (first segment of the video) can drive forward movement of cells suspended in liquid, whereas GPCR activation (second segment), which is involved in propelling adherent cells, does not work in suspension.

Check out the paper at https://www.cell.com/developmental-cell/fulltext/S1534-5807(18)30422-2

O'Neill, P.R., Castillo-Badillo, J.A., Meshik, X., Kalyanaraman, V., Melgarejo, K., and Gautam, N. (2018). Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode. Developmental Cell. 46.

And read more great research at Developmental Cell: https://www.cell.com/developmental-cell/home

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