Tracking Immunoevasion / Cell, November 30, 2017 (Vol. 171, Issue 6)

621 views · Published 7 December 2017 · 1:23 · Indexed 29 October 2026

Channel: Cell Press · 2017 · Science & Technology

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When cancer cells lose the ability to present neoantigens to immune cells through human leukocyte antigen (HLA) loss, they are able to evade the body’s immune response. Now, Swanton and colleagues present a computational tool that allows researchers to determine whether a tumor has genetic alterations the HLA genes by looking at sequencing data. Check out the paper at: http://www.cell.com/cell/fulltext/S0092-8674(17)31185-6.

N. McGranahan, R. Rosenthal, C.T. Hiley, A.J. Rowan, T.B.K. Watkins, G.A. Wilson, N.J. Birkbak, S. Veeriah, P. Van Loo, J. Herrero, et al. (2017). Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution. Cell 171.

And read more great research at http://www.cell.com/cell/home.

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