Bessel Beam Bedazzles
851 views · Published 6 December 2018 · 0:08 · Indexed 16 October 2026
Channel: Cell Press · 2018 · Science & Technology
To generate a filopodium on the cell surface, parallel actin filaments nucleate at a small patch of membrane and then thrust forward like a dart gun. On making contact with another cell or extracellular matrix proteins, the filopodium may mature into a focal adhesion, forming a more stable anchor and providing traction necessary for cell motility. Filopodia on the surface of a HeLa cell imaged with Bessel beam plane illumination microscopy. In beam plane illumination microscopy, a super-thin sheet of light scans the cell surface, like a supermarket barcode reader. Recently, the Betzig laboratory improved this technique so that ~10,000 frames can be acquired from a single living cell at nearly 200 frames/sec. Video courtesy of Liang Gao, Betzig Lab, Janelia Farm. See more cell motility images in the Cell Picture Show: https://www.cell.com/pictureshow/cell-motility
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