Assembly and Functions of a Viral Polymer that Inactivates Multiple Tumor Suppressors

1,911 views · Published 11 October 2012 · 5:56 · Indexed 30 September 2026

Channel: Cell Press · 2012 · Science & Technology

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Clodagh O'Shea and colleagues describe how they used a combination of ultrastructural, crystallography, and biochemical studies to show that the adenoviral protein E4-ORF3 forms a multivalent polymer that can simultaneously sequester several cellular tumor suppressor proteins.

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